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J Neurosonol Neuroimag > Volume 16(1); 2024 > Article
Journal of Neurosonology and Neuroimaging 2024;16(1):1-7.
DOI: https://doi.org/10.31728/jnn.2024-00154    Published online June 30, 2024.
Correlation Between Elevated Lipoprotein(a) and Carotid Plaque in Asymptomatic Individuals
Minsoo Sung, MD1; Yo Han Jung, MD, PhD1,2; Young Hoon Youn, MD, PhD3; Kyung-Yul Lee, MD, PhD1,2
1Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
2Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Korea
3Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Correspondence:  Kyung-Yul Lee, MD, PhD, Tel: +82-2-2019-3325, Fax: +82-2-3462-5904, 
Email: kylee@yuhs.ac
Received: 22 April 2024   • Revised: 10 June 2024   • Accepted: 16 June 2024
Abstract
Background
Carotid plaque formation is a major global health issue and contributes in pathogenesis of vascular diseases. Lipoprotein(a), similar to low-density lipoprotein, may influence atherogenesis by promoting inflammation and thrombosis. However, the association between lipoprotein(a) levels and presence of carotid plaques has been debated. This study investigated the correlation between these parameters.
Methods
We retrospectively analyzed 4,896 individuals who underwent lipoprotein(a) measurement and carotid ultrasonography at Gangnam Severance Hospital between January 2017 and December 2022. The relationship between lipoprotein(a) levels and the presence of carotid plaques was evaluated using logistic regression analysis adjusted for factors such as age, sex, hypertension (HTN), dyslipidemia, and diabetes mellitus (DM).
Results
Among the 4,896 enrolled participants, those with carotid plaques were older, more likely to be men, and had a higher prevalence of HTN, DM, and dyslipidemia. The analysis showed a significant association between the presence of carotid plaques and a level of lipoprotein(a) ≥50 mg/dL in both univariable (unadjusted odds ratio=1.508, p<0.001, 95% confidence interval: 1.192–1.907) and multivariable (adjusted odds ratio=1.335, p=0.029, 95% confidence interval: 1.030–1.731) models.
Conclusion
Elevated lipoprotein(a) level emerged as an independent risk factor for carotid plaque formation, emphasizing the need for integrated risk assessment. Targeting lipoprotein(a) could enhance preventive strategies against cerebrovascular events. Therefore, further research is warranted to elucidate this disease’s underlying mechanisms and evaluate therapeutic interventions.
Key Words: lipoprotein(a); carotid stenosis; carotid ultrasound; dyslipidemias


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