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J Neurosonol Neuroimag > Volume 16(1); 2024 > Article
Journal of Neurosonology and Neuroimaging 2024;16(1):8-15.
DOI: https://doi.org/10.31728/jnn.2024.00153    Published online June 30, 2024.
Association of Cerebral Artery Stenosis with Blood Viscosity in Patients with Transient Ischemic Attack
Young Chan Jung, MD; Sang Won Han, MD; Joong Hyun Park, MD
Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
Correspondence:  Joong Hyun Park, MD, Tel: +82-2-950-8849, Fax: +82-2-950-8850, 
Email: truelove1@hanmail.net
Received: 17 April 2024   • Revised: 22 June 2024   • Accepted: 23 June 2024
Abstract
Background
Blood viscosity (BV) reflects blood thickness and stickiness, crucial for vascular health. Elevated BV is linked to stroke risk factors, suggesting a role in transient ischemic attacks (TIA).
Methods
This retrospective observational study investigated BV levels in TIA patients with and without cerebral artery stenosis. Patients admitted within 24 hours of symptom onset between March 2017 and December 2021 were included. Baseline characteristics, including demographics and vascular risk factors, were assessed. BV measurements were obtained within 24 hours of symptom onset using a scanning capillary-tube viscometer. Patients were categorized into TIA groups based on the presence or absence of cerebral artery stenosis.
Results
Of the 153 TIA patients screened, 86 were included for analysis. The mean age was 62.6 years, with a predominance of hypertension (59%) and dyslipidemia (45%). Patients with cerebral artery stenosis (TIA-AT group, n=56) exhibited significantly higher BV levels within 24 hours of symptom onset compared to those without stenosis (TIA-E group, n=30). This finding suggests a potential link between underlying pathophysiological mechanisms of TIA and BV levels.
Conclusion
Despite the limitations of a single-center, retrospective study, this research suggests that there is evidence of increased blood viscosity in patients with TIA who have cerebral artery stenosis, implying that blood viscosity may play a role in the pathophysiology of TIA. Further research involving larger cohorts is warranted to elucidate the precise mechanisms linking BV to TIA and to validate its utility as a prognostic marker and therapeutic target in TIA management.
Key Words: transient ischemic attack; stenosis; stroke; viscosity


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