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Journal of Neurosonology 2012;4(1):1-7.
Current Status of Sonothrombolysis and its Future
초음파혈전용해술의 현재와 미래
Abstract
Thrombolytic treatment with intravenous (IV) tissue plasminogen activator (t-PA) is a proven therapy in acute ischemic stroke patients. Successful recanalization is a strong determinant for favorable outcome in patients who received thrombolytic treatments. In the last few decades, thrombolysis with ultrasound has been tested whether this modality can improve the successful recanalization rate or clinical outcomes. Three different ultrasound technologies including transcranial Doppler, transcranial color-coded sonography, and low-frequency ultrasound were used to increase the thrombolytic efficacy of IV t-PA. Because microbubbles can lower the amount of ultrasound energy needed for acoustic cavitation, concomitant use of microbubbles with ultrasound has been also tested for the presence of additional benefits in sonothrombolysis. This article reviews the present status of sonothromboolysis in acute ischemic stroke and discusses its future.
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